On the surface of it: the role of materials science in developing antifungal therapies and diagnostics
Bryan R Coad
+ Author Affiliations
- Author Affiliations
Mycology/Surface Interfaces Group
Mawson Institute
University of South Australia
Mawson Lakes, SA 5059, Australia
Tel: +61 8 8302 3152
Email: bryan.coad@unisa.edu.au
Microbiology Australia 36(2) 71-73 https://doi.org/10.1071/MA15024
Published: 16 March 2015
Abstract
Surfaces are often considered to play a passive role in clinical mycology; that is, the outward face of a medical device to which fungal cells attach and form biofilms. However, materials chemistry and nanotechnology are now transforming passive surfaces into active interfaces and driving innovation into antifungal agents, their surface delivery and mechanisms, and diagnostic devices. Beyond technological improvements, there is great opportunity to drive basic research into fungal-surface interactions; however, this can only be accomplished with combined and concerted efforts of materials scientists, polymer chemists and mycologists.
References
[1] Hidron, A.I. et al. (2008) NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect. Control Hosp. Epidemiol. 29, 996–1011.| NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007.Crossref | GoogleScholarGoogle Scholar | 18947320PubMed |
[2] Stone, P.W. et al. (2005) The economic impact of infection control: making the business case for increased infection control resources. Am. J. Infect. Control 33, 542–547.
| The economic impact of infection control: making the business case for increased infection control resources.Crossref | GoogleScholarGoogle Scholar | 16260329PubMed |
[3] Crump, J.A. and Collignon, P.J. (2000) Intravascular catheter-associated infections. Eur. J. Clin. Microbiol. Infect. Dis. 19, 1–8.
| Intravascular catheter-associated infections.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3c7mvVKruw%3D%3D&md5=24edf4f32ebea329b411cf2faa4494b4CAS | 10706172PubMed |
[4] Marriott, D. et al. (2006) Candidaemia in the Australian intensive care unit: epidemiology, clinical features and outcome from a 3 year nationwide study. Int. J. Infect. Dis. 10, S77–S78.
| Candidaemia in the Australian intensive care unit: epidemiology, clinical features and outcome from a 3 year nationwide study.Crossref | GoogleScholarGoogle Scholar |
[5] Hachem, R. et al. (2009) Novel antiseptic urinary catheters for prevention of urinary tract infections: correlation of in vivo and in vitro test results. Antimicrob. Agents Chemother. 53, 5145–5149.
| Novel antiseptic urinary catheters for prevention of urinary tract infections: correlation of in vivo and in vitro test results.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsF2gs7bO&md5=75c8d722fe8312d5cf5a5f0e1d831ea1CAS | 19805562PubMed |
[6] Zumbuehl, A. et al. (2007) Antifungal hydrogels. Proc. Natl. Acad. Sci. USA 104, 12994–12998.
| Antifungal hydrogels.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXpt1KrtLY%3D&md5=c3f1fba1ff4b921d5571f600ae848544CAS | 17664427PubMed |
[7] Desseaux, S. and Klok, H.-A. (2015) Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: ligand co-presentation and 3D-localization. Biomaterials 44, 24–35.
| Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: ligand co-presentation and 3D-localization.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXhs1KisQ%3D%3D&md5=0efe46809c0ffefc95873e2e6d15fe6eCAS | 25617123PubMed |
[8] Gow, N.A. et al. (2012) Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat. Rev. Microbiol. 10, 112–122.
| 1:CAS:528:DC%2BC3MXhs1aitr%2FK&md5=588e7420bcd309172a4857162b3f2783CAS |
[9] Hickey, P.C. et al. (2004) Live-cell imaging of filamentous fungi using vital fluorescent dyes and confocal microscopy. Method. Microbiol. 34, 63–87.
| Live-cell imaging of filamentous fungi using vital fluorescent dyes and confocal microscopy.Crossref | GoogleScholarGoogle Scholar |
[10] Coad, B.R. et al. (2014) Biomaterials surfaces capable of resisting fungal attachment and biofilm formation. Biotechnol. Adv. 32, 296–307.
| Biomaterials surfaces capable of resisting fungal attachment and biofilm formation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhvVagt77M&md5=5176e1a71e22e7843e55d3475ab18048CAS | 24211473PubMed |
[11] Brown, G. D. et al. (2012) Hidden killers: human fungal infections. Sci. Transl. Med. 4, 165rv13.
| Hidden killers: human fungal infections.Crossref | GoogleScholarGoogle Scholar | 23253612PubMed |
[12] Gow, N.A.R. et al. (2012) Waging war on fungi – the unknown superbugs. Microbiol. Today 39, 208–211.
[13] Peleg, A.Y. et al. (2010) Medically important bacterial-fungal interactions. Nat. Rev. Microbiol. 8, 340–349.
| Medically important bacterial-fungal interactions.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXjvFars7g%3D&md5=a51a08457e9d01185bafbcabf719a2cdCAS | 20348933PubMed |
