Current Articles


Moving towards HIV treatment as prevention

HIV prevention has entered a new and exciting era. In lieu of discovering an HIV cure or developing an effective vaccine, ‘combination prevention' is likely to underpin HIV prevention globally over coming decades1. Within the combination prevention framework, the concept of treatment as prevention (TasP) is attracting the most enthusiasm2.

Mark A StoovĂ©, Alisa E Pedrana and Margaret E Hellard     16-Apr-2014
Immune reconstitution disorders in HIV patients receiving antiretroviral therapy

Suppression of HIV infection by antiretroviral therapy (ART) resolves much of the immune dysfunction caused by HIV replication. However, reconstitution of the immune system during ART may, paradoxically, cause immunological disease that presents clinically as an immune reconstitution disorder. These disorders include autoimmune disease, mainly Graves' disease, and immune-mediated inflammatory disease, such as sarcoidosis. However, by far the most common type of immune reconstitution disorder results from restoring immune responses against oppor...

Martyn A French     16-Apr-2014
Inflammation and innate immune activation in chronic HIV infection

Presently, there is no effective therapeutic HIV vaccine or a protective vaccine against de novo infection, and antiretroviral therapy is the only effective treatment for the many people currently infected with HIV. Current antiretroviral regimens, while effective at controlling HIV viremia, do not reduce inflammation and innate immune activation increased in chronically infected HIV+ individuals, who suffer increased prevalence of non-AIDS co-morbidities with an inflammatory aetiology. An understanding of the causes, and development of ...

Anthony Jaworowski and Anna C Hearps     16-Apr-2014
Promoter targeted small RNAs: stabilising viral reservoirs

The viral reservoir, a major barrier to curative therapy for HIV-1 infection, consists of viral DNA sequestered in long-lived resting CD4+ T cells and macrophages in diverse anatomical sites. Some of these sites are recognised parts of the immune system, such as lymph nodes. Others, such as the brain are not 1. Current anti retroviral therapy (ART) does not substantially impact upon this reservoir. Early intervention with ART limits the reservoir but does not result in its elimination25....

Anthony D Kelleher     16-Apr-2014


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Pathology of Australian Native Wildlife

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All the available information on the anatomical pathology of Australian native vertebrate wildlife.