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RESEARCH ARTICLE

Influenza

John S Mackenzie A B G , Anne Kelso C and Alan W Hampson D E F
+ Author Affiliations
- Author Affiliations

A Faculty of Health Sciences
Curtin University
GPO Box U1987
Perth, WA 6845, Australia. Tel: +61 4 3987 5697

B Burnet Institute
85 Commercial Road
Melbourne, Vic., Australia

C WHO Collaborating Centre for Reference and Research on Influenza (VIDRL)
at the Peter Doherty Institute for Infection and Immunity
792 Elizabeth Street
Melbourne, Vic. 3000, Australia. Tel: +61 3 9342 9310
Email: anne.kelso@influenzacentre.org

D School of Applied Sciences and Engineering
Federation University

E Influenza Specialist Group

F 5A Lynne Street, Donvale, Vic. 3111, Australia. Tel: +61 3 9894 5049
Email: Interflu@bigpond.net.au

G Corresponding author. Present address: 20A Silver Street, Malvern, Vic. 3144, Australia. Email: j.mackenzie@curtin.edu.au

Microbiology Australia 35(3) 133-137 https://doi.org/10.1071/MA14045
Published: 24 July 2014

Abstract

Influenza virus infection has probably shaped human populations for centuries, if not millennia. Novel influenza viruses formed by genetic reassortment of avian and mammalian viruses emerge sporadically and, if they have the necessary infectivity and transmissibility in humans, spread rapidly around the globe causing a pandemic. While mortality and morbidity varied widely between the pandemics of the last century, the loss of an estimated 50million lives in the most devastating pandemic of 1918–1919 has had a lasting global impact. Here we briefly review the history and effects of influenza pandemics on the global human population and events of the time. Then we discuss some of the ways in which the experience of the 1918–1919 and later pandemics has influenced development of international influenza surveillance and global public health policy, the full impact of which will become apparent in future pandemics.


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