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Microbiology Australia Microbiology Australia
Issue 5

Vertical Transmission, November 2002

It is a great honour for me to become President of ASM and I look forward to the challenges that the next 2 years will provide.

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Watch this space

This issue of Microbiology Australia will focus on the major steps of drug discovery and development. The continued discovery of therapeutic agents is an issue of concern for every society and, to a large extent, now transcends the parochialism of ?national benefit?.

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Strategies for identifying new antimicrobial targets

The increasing number of human pathogens resistant to existing classes of antibiotics has made the identification of novel antimicrobial agents a matter of urgency. The fact that no new class of broad spectrum antibiotics has been developed since the 1970s highlights the symptom that the majority of current antibiotics have been targeted against a limited number of bacterial cellular processes. These can be generally classed as inhibitors targeted against cell wall biosynthesis, DNA/RNA replication, protein synthesis or specific biochemical bot...

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Hypothesis driven drug discovery

Antibiotics were discovered over 50 years ago, providing a long sought after treatment for infectious diseases. These drugs effectively suppressed diseases such as tuberculosis and infections such as those caused by Staphylococcus aureus.

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Proteome analysis for antimicrobial drug development and target validation

Earlier this year, I provided a review of the technologies involved in studying microbial physiology using proteomics. This global analysis of protein expression can be utilised to discover novel targets for vaccines, antimicrobial therapeutics and diagnostics, as well as to determine the cellular effects and interaction partners of newly synthesized compounds. Furthermore, the technology has also been applied to comparisons of bacterial strains that differ in their resistance to commonly used antibiotics.

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Genomics and drug discovery

Genomics represents a new tool in drug discovery. Microbial genomics have been at the forefront of a new era of whole cell molecular biology because genomic data provides a quantum leap in available genetic data. But while the tool is valuable and important, it is not the complete answer.

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Old therapies, new science

With the emergence of antibiotic resistance as a major public health problem and the apparent decline in pharmaceutical company drive to produce new antimicrobials, there has been an increase in interest in revisiting remedies and agents once popular before the advent of the antibiotic era.

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Fast tracking drug development: balancing risks and rewards

The biotechnology revolution offers great hope for new therapies based on rational approaches to target discovery and drug design based on genomics, proteomics, advanced chemistry (3-D modelling, combinatorial chemistry) and high throughput screening.

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Trials and tribulations of veterinary drugs

In general terms, the discovery and development of drugs for veterinary use follows the processes and procedures used for human drug discovery. Some interesting differences do arise, however. For example, when developing veterinary drugs it is necessary to be aware of the great diversity in physiology and disease profiles of the various species of animals, birds and fish for which new drugs may be sought. Hence, veterinary drugs may need to be targeted at specific species, rather than just for animals in general. Routes of delivery also can be ...

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Blastocystis or Dientamoeba? Morphological similarities when fixed and stained

Many laboratories will use a wet preparation of faeces to check for enteric protozoa. The appearance of Blastocystis hominis in these films is straightforward.Dientamoeba can be present as well but itrequires an enormous amount of skill to identify if you have not prepared a fixed and stained smear. The appearance of these two organisms in the iron haematoxylin stain can be very similar.

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ASM Affairs, November 2002

Young Bugs Banter; Conference Report; Rubbo Orators: Past and Present; 2002 BD Award Winners; ASM 2002 Annual Scientific Meeting; ASM 2002: microbiologists make a difference

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